The Clinical Research Department of the Research and Development Division of M/s Ayurvet Limited published its 700th research communication in January. In fulfillment of its motto of providing safe, efficacious, and dependable solutions for improving the quality of animal life based on traditional knowledge backed by modern research, Ayurvet’s R&D remains devoted to bringing in the most advanced scientific tools and technical know-how right from the conceptualization of a product up to the validation and re-validation of its efficacy and safety. Beginning since 1992, Ayurvet’s R&D has published an average of two scientific communications every month. The 700th publication, ‘Phytogenic feed-additives improve broiler feed efficiency via modulation of intermediary lipid and protein metabolism-related signaling pathways’ appeared in Poultry Science. Undertaken in collaboration with the Centre of Excellence for Poultry Science at the University of Arkansas, USA, the work presented in this publication unearths, for the first time ever, the peripheral mechanisms, which operate in the liver, fat tissue, and muscles of broilers receiving phytogenic supplements and that contribute to their improved feeding efficiency and growth performance. It is noteworthy that Ayurvet’s R&D had previously also uncovered, for the first time in the world, the central mechanisms operating in the brains of the broilers receiving phytogenic supplements that contribute to their improved feeding efficiency and growth performance; the work titled, ‘Phytogenic feed- and water-additives improve feed efficiency in broilers via modulation of (an)orexigenic hypothalamic neuropeptide expression’ was published in the renowned journal Neuropeptides.
Ayurvet’s R&D has been regularly involved in path-building research that offers unique insights into the activity and efficacy of herbals and phytogenics. The demonstration of the modulation of cytokines and inflammatory markers within the udder environment by the topical application of a herbal, anti-mastitic ointment; the modulation of ruminal microbial populations and reduction in methanogenesis by phytogenic rumenotorics; the reverse pharmacological identification of the molecular targets of a polyherbal, oral uterine cleanser and restorative; and the in silico modeling of the mechanism of a polyherbal anti-stressor for livestock are some prominent “first-in-the-world” research feats of Ayurvet. The R&D is going from strength to strength and continues to take up advanced research projects in areas of fluxomics, reverse pharmacology, metagenomics, and metabolomics toward creation of the scientific impetus required for driving herbalism as a sustainable solution for animal and one health. Ayurvet’s R&D believes that such mechanistic studies will not only help the company in strengthening its own presence in the industry but also earn much-needed faith and conviction for traditional herbal knowledge.