Page 12 - Think Grain Think Feed - Noc 2025 Issue

www.benisonmedia.com ARTICLE Think Grain Think Feed - Volume 12 | Issue 1 | Nov 2025 monsoon season. This co- (Sandberg, F. B. et al., 2007; Management www.benisonmedia.com

Think Grain Think Feed - Volume 12 | Issue 1 | Nov 2025

one toxin. This is especially
relevant in Indian conditions,
occurrence leads to
Klasing, K. C., 2007) when
Having a comprehensive
where feed ingredients are
measured in simulated
significant shifts in the gut
mycotoxin screening strategy
microbiota, with reductions
models. Translating
often contaminated with
to assess total burden rather
commercially, the losses
in beneficial lactic acid
more than one mycotoxin
than single-toxin and
Ingredient Factors
could be estimated to be
bacteria and increases in
due to climatic and storage
Employing a broad-spectrum
for Gut Health Insult factors. The practical pathogenic bacteria, about 60g of feed lost per
toxin binder effective against
Various factors affect the ingredient quality implication is that predisposing flocks to broiler amounting to almost
polar and non-polar classes
eventually leading to gut health insult. compliance with individual enteric diseases and poor Rs 2.5 to 3 per broiler bird.
can reduce luminal
However, in current situations predominantly mycotoxin limits does not performance (Gowda et al., Undesired intestinal
the effect of microbial contamination, guarantee safety—risk 2013; Reddy et al., 2020). inflammation weakens gut bioavailability and protect
mycotoxin related enteritis and certain anti- barrier function.
assessments and Furthermore, changes in the integrity and aggravates
nutritional factors appear to be the major Additionally, mitigating the
management strategies must microbiota can alter the dysbacteriosis, promotes
reasons. unseen risk of pesticide
consider the total mycotoxin metabolism of nutrients and translocation of pathogens
residues by using relevant
burden and the possibility of even create a vicious cycle of from gut into system and
binders could be an effective
interactions (Malekinejad et gut health decline. importantly puts the gut in
practice
al., 2011; Gao et al., 2020; Effect of Mycotoxins on oxidative stress further
Palacios-Cabrera et al., 2025). Gut Inflammation compromising the immune Post-harvest & Storage
Effect of Mycotoxins on Mycotoxins are potent function associated with gut. Controls
Mycotoxins Poultry Gut Microbiota triggers of gut inflammation. Eventually, the diversion of Prefer conditioning/holding
nutrients to bring about an new maize > 8 weeks where
Mycotoxins can significantly They cause both acute and
inflammatory response possible; when not feasible,
disturb the gut microbiota, chronic inflammatory
reflects in economic losses. mix NM with AM (e.g., 1:2 or
leading to dysbiosis—a shift responses by damaging the 2:1) to dilute ANFs and
in the balance of beneficial gut lining and disrupting Management and
and harmful bacteria. Studies immune regulation. Chronic Mitigation: What to Do performance penalty
CPA (Cydopiazonic acid) CPA has additive affects with Mycotoxins not only result in in poultry have shown that inflammation, often seen When We Must Use New suggested by organ-weight
levels have been observed Aflatoxins and doses even at necrotic changes in Liver, Kidney, and F/G data (Zhong et al.,
at higher levels 50 ppb have reported negative Gizzard and Proventriculus but also mycotoxins reduce with ongoing mycotoxin Maize
(Kemin Internal Data) effects have been reported to cause populations of beneficial exposure diverts nutrients Microbiota & Gut Integrity 2019).
(Malekinejad et al. 2010) significant oxidative stress build up Mechanical drying to safe
(Malekinejad et al. 2010) bacteria such as Lactobacillus away from growth, reduces Support
and Bifidobacterium, while feed efficiency, and can A strategy is needed to moisture before binning;
allowing pathogenic bacteria worsen tissue injury. maintain strong protection maintain aeration and
1 High contamination 2 3 Usage of 4 Methods for NSP hygiene to limit mold
Raw Rancidity in oils like E. coli and Clostridium Mycotoxins like aflatoxins, against Necrotic Enteritis,
of animal source alternate raw estimation through
Material proteins with and oil cakes material wet chemistry are perfringens to proliferate. trichothecenes and CPA have which remains a major gut- growth.
Alert Clostridia resulting in vent resulting in still empirical which Formulation & Processing
pasting
perfringens and higher quantities are difficult to apply This disturbance impairs gut been shown to increase pro- health issue in poultry. Since,
E. coli of NSP’s (Non in commercial barrier function, increases inflammatory cytokines (e.g., new maize could result in gut Addressing resistant starch
Starch operation leading
Polysaccharides to variations inflammation, and reduces TNF-α, IL-1β), reduce anti- damage further acting as by inclusion of
the bird's ability to resist inflammatory mediators, and predisposing factor for NE. amylase/glucoamylase and
infections. In Indian climatic impair the gut's ability to xylanase/NSPase and to
address all four barriers, not combined effects can be Keeping in mind the
conditions, the risk of return to a healthy, balanced support duodenal digestion
just focus on pathogen additive or even synergistic. inflammatory effects, a
mycotoxin-induced gut state. This not only increases could be a helpful strategy
control and a strategy could This means that the total strategy to counter gut
microbiota disturbance is disease risk but also impacts along with considering
be mitigation of underlying damage to the gut barrier, inflammation simultaneous
particularly high due to the flock performance and phytase optimization and
gut inflammation immune system, and overall to microbiota balance is
country's warm, humid productivity (Malekinejad et Ca/P re-balancing to offset
development. bird health can be much becoming a must to
climate, variable post-harvest al., 2011, Broom & Kogut, effectively manage poultry the selective mineral-
Effect of Combined greater than expected from practices, and reliance on 2018; Guerre, 2020). utilization deficit seen with
Mycotoxins Even Within any single toxin alone. For maize and other susceptible For field application, “gut gut health and subsequent new maize
litter quality.
Recommended Levels example, birds exposed to grains in poultry feed. inflammation” develops due Energy matrix & amino acids:
both aflatoxins and CPA In this regard a combination
Research consistently shows Indian studies and field to multiple factors in which Recognizing the lower GE
(Cyclopiazonic acid) at “safe” strategy of proven Bacillus
that when multiple reports have documented presence of mycotoxins and DM of new maize and
levels may experience more strains with potent specific
mycotoxins are frequent co-contamination appears to be one of the adjusting energy and amino
severe gut barrier anti-inflammatory
present—even if each is of feed with aflatoxins and core reasons. It comes at the acid density accordingly.
breakdown, immune photoactive could pave a
below its individual trichothecenes, especially expense of about 0.27 g of Detailed references available upon
suppression, and dysbiosis way forward.
regulatory threshold—their during and after the ideal protein per bird per day request
than those exposed to just Mycotoxin Risk
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