Page 27 - Think Grain Think Feed - April'25

www.benisonmedia.com ARTICLE mortality (up to 30%), pale to produce energy, · Vaccination Programs:

Think Grain Think Feed - Volume 11 | Issue 6 | April 2025

Vaccinate against viral
thereby preventing
combs, and depression.
pathogens like
hepatic lipidosis
Clinical signs include
adenoviruses to prevent
depression, pale combs, and
(Hoppel, 2003).
high mortality. Necropsy
Antioxidants and
reveals enlarged, yellow,
conditions (PubMed,
2016).
crumbly livers with Mycotoxin Binders: Use viral hepatitis and related
vitamin E, selenium, and
hemorrhages and feed additives to 4. Stress Reduction
intranuclear inclusion neutralize toxins and Reduce environmental and
bodiesin hepatocytes, as well oxidative stress. handling stressors to
as enlarged, pale, mottled
Other nutritional improve metabolic and
kidneys. IBH is often
interventions: Dietary immune resilience.
associated with
fiber promotes gut 5. Genetic and molecular
immunosuppressive diseases
microbial fermentation;
like Infectious Bursal Disease methods
phytogenics (such as
or Chicken Infectious Anemia Selective breeding for genes
curcumin and oregano
(Dinev, 2023).Prevention related to gut integrity (e.g.,
oil) offer
includes avoiding hatching occludin, claudin) and liver
hepatoprotective and
eggs from infected flocks detoxification (e.g.,
antibacterial effects;
and limiting wild bird access cytochrome P450 enzymes)
omega-3 fatty acids
(Dinev, 2023). enhances disease resistance.
support the liver-gut
Mitigating Strategies axis by reducing pro- CRISPR-Cas9 enables
targeted gene editing to
1. Nutritional inflammatory cytokines
improve traits such as
Management and boosting anti-
antioxidant enzyme activity
inflammatory mediators,
Balanced Diet and antimicrobial peptide
Formulation: Maintain thereby improving liver production (Gao et al., 2023).
appropriate calorie-to- health (Calder, 2015);
and in ovo stimulation Conclusion
protein ratios.
Supplement essential enhances hepatic Maintaining poultry liver
nutrients like vitamins antioxidant enzyme health is vital for productivity
activity (Das et al., 2021). and overall well-being. The
B12, E, and choline to
liver's central role in
support fat metabolism. 2. Biosecurity Measures
Monitoring feed intake Implement strict detoxification, metabolism,
and body weight and nutrient storage makes it
biosecurity: control
regularly allows access, sanitize especially vulnerable to
producers to adjust diets equipment, monitor dietary imbalances, toxins,
accordingly to prevent and infections. Conditions
health, and maintain
obesity and associated optimal housing and like Fatty Liver Syndrome,
liver issues. ventilation (Borda- mycotoxin-induced liver
damage, Spotty Liver
Lipotropic Agents: Add Molina et al., 2025;
Disease, and Inclusion Body
choline (250 ppm in Sciendo, 2025).
Hepatitis pose significant
rearing; 500–1000 ppm 3. Disease Prevention threats. A comprehensive
during production), Strategies approach—combining
methionine, and inositol.
· Immunotherapy: optimized nutrition,
L-Carnitine: Facilitates
Interleukin-2 (IL-2) biosecurity, vaccination, and
mitochondrial fatty acid enhances T-cell activity; stress reduction—can
oxidation by interferon-gamma (IFN-γ) preserve liver function,
transporting long-chain
boosts innate immunity enhance productivity, and
fatty acids into the and reduces hepatic support sustainable poultry
mitochondrial matrix, pathogens (Rothwell et farming.
where they are oxidized
al., 2004).
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